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KMID : 0882420160900050460
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Korean Journal of Medicine
2016 Volume.90 No. 5 p.460 ~ p.463
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Myelodysplastic Syndrome (RAEB-II) Development 2 Months after Chemotherapy for a Primary Non-seminomatous Mediastinal Germ Cell Tumor
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양범희:Yang Bum-Hee
신선혜:Shin Sun-Hye/김지혜:Kim Ji-Hye/김민선:Kim Min-Sun/박실비아:Park Silvia/장준호:Jang Jun-Ho/정철원:Jung Chul-Won
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Abstract
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Here, we report on a 20-year-old patient with a primary nonseminomatous mediastinal germ cell tumor (MGCT) who developed myelodysplastic syndrome (MDS) 2 months following chemotherapy with cisplatin, etoposide, ifosfamide, and paclitaxel. Bone marrow examinations revealed that the MDS was a refractory anemia with excess type II blasts and complex chromosomal abnormalities. With the onset of MDS occurring rapidly following chemotherapy, it is unlikely to have been caused by the therapy. We discuss the association between primary nonseminomatous MGCTs and hematological malignancies, including the possibility of a common clonal origin.
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KEYWORD
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Mediastinal germ cell tumor, Myelodysplastic syndromes, Therapy-Related
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